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Oncotarget 7 , 1422014240 (2016)

This decline correlates with reduced wound healing capacity, thinner skin, decreased collagen synthesis, and other hallmarks of tissue aging

The exact mechanisms are complex, but broadly NAD+ injections may counteract NAD+ depletion and support better cellular function, especially in high-demand tissues like the brain and muscles

A few research studies have suggested that non-protein nitrogen serves other functions in enzyme regulation, bioactive component storage, gut microbiome development, mucosa development, and immune function but our understanding of the function of non-protein nitrogen is limited